SPRAVATO® Treatment for Treatment-Resistant Depression

Available Exclusively at Our Broadview Heights, OH and Roanoke, VA Locations

SPRAVATO® (esketamine) is an FDA-approved nasal spray designed for adults experiencing treatment-resistant depression or major depressive disorder with suicidal thoughts or behaviors. At D2HP Centers, our team provides SPRAVATO® in a safe, private environment with continuous clinical supervision to ensure comfort and stability throughout treatment.

What Is SPRAVATO®?

SPRAVATO® is a prescription nasal spray derived from esketamine, a medication that works on the brain’s glutamate system to restore healthy neural communication. Unlike traditional antidepressants that may take weeks to begin working, SPRAVATO® can provide meaningful relief within hours to days. It is taken in combination with an oral antidepressant and administered only in a clinical setting under professional supervision.

rTMS is ideal for adults who have not experienced success with traditional depression treatments or are looking for an alternative option. It is commonly recommended for patients with treatment-resistant depression, generalized anxiety disorder, PTSD, and other related conditions. If you are struggling with mood regulation and are seeking a safe, non-invasive solution, rTMS may be right for you.

Boosts Neural Activity

SPRAVATO® helps activate glutamate receptors, which play a key role in regulating mood and emotional processing. This helps “re-ignite” neural pathways that have become underactive due to depression.

Improves Mood Fast

Many patients begin experiencing relief within the first 24–48 hours. SPRAVATO® provides rapid symptom improvement, especially for individuals who have not responded to multiple antidepressants.

Restores Brain Connections

SPRAVATO® supports the regrowth of damaged or dormant synapses, helping the brain develop healthier patterns over time and improving long-term stability.

SPRAVATO® may be recommended if you have not achieved adequate relief from at least two different antidepressant treatments. It may also be an option if you are experiencing major depressive disorder with persistent or worsening symptoms despite therapy, medication, or other treatments.

Before beginning treatment, our providers complete a detailed evaluation to ensure SPRAVATO® is safe and appropriate for your individual needs.

Accepted Insurance:

We understand that navigating insurance coverage for new treatments can be overwhelming. Our team is here to help you through the process and verify your benefits.

Service Locations:

Experience SPRAVATO®

What to Expect During a SPRAVATO® Session

Every SPRAVATO® appointment takes place in a private, calming treatment room at our Broadview Heights location. You will self-administer the medication under the guidance of our clinical team, followed by a monitored relaxation period.

1. Preparation

You will blow your nose and receive instructions from your provider before administering the nasal spray.

2. Self-Administration

You administer SPRAVATO® by spraying once into each nostril, guided step-by-step by our team.

3. Monitoring & Relaxation

For about two hours, you will remain in the office as our clinicians monitor your safety and comfort. Many patients listen to music, rest, or use an eye mask during this time.

Treatment Timeline

Your SPRAVATO® Treatment Schedule

Weeks 1–4

Two sessions per week

Weeks 5–8

One session per week

Week 9 and beyond

Maintenance treatments as needed

SPRAVATO® therapy follows a structured treatment protocol recommended by the FDA. Your provider will tailor your plan based on your progress and long-term goals.

Many patients experience rapid improvement early in treatment, with continued benefits through the full course.

Join Our Wellness Community

Available Only at Our Broadview Heights, OH Location

SPRAVATO® therapy is exclusively offered at our Broadview Heights center. Patients from across Northeast Ohio trust our team for advanced, research-backed treatment options delivered in a comfortable and supportive environment.

Submit Your SPRAVATO® Referral to D2 Human Performance Centers

SPRAVATO® Patient Referral Form

To refer a patient for SPRAVATO® treatment, please download and complete the SPRAVATO® Patient Referral Form. This form helps us collect essential clinical details needed to evaluate eligibility and begin the referral process. Once completed, fax the form to 888-357-5588 so our team can promptly review and reach out with next steps.